Document 0803
 DOCN  M94B0803
 TI    Short, terminally phosphorylated oligoriboguanylic acids effectively
       inhibit cytopathicity caused by human immunodeficiency virus.
 DT    9412
 AU    Fujihashi T; Sakata T; Kaji A; Kaji H; Department of Pharmacology,
       Jefferson Medical College,; Philadelphia, PA 19107.
 SO    Biochem Biophys Res Commun. 1994 Sep 15;203(2):1244-50. Unique
       Identifier : AIDSLINE MED/94380036
 AB    Various synthetic ribonucleic acids were evaluated for inhibition of
       HIV-induced cytopathicity of cultured cells; only poly and oligoguanylic
       acids, but not other homopolymers, showed potent inhibitory activity.
       Phosphorylation of either the 5'- or 3'-end of oligoribonucleotides
       converted short inactive oligomers, such as dimers to effective anti-HIV
       agents. The efficacy of the 3'-phosphorylated phosphorothioate trimer of
       guanylic acid was comparable to that of other longer oligonucleotides so
       far reported. Phosphorothioate oligoriboguanylic acids were superior to
       the corresponding oligodeoxyguanylic acids in their capacity to prevent
       HIV cytopathicity.
 DE    Antiviral Agents/*PHARMACOLOGY  Cell Line  Comparative Study
       Cytopathogenic Effect, Viral/*DRUG EFFECTS  DNA/ANTAGONISTS &
       INHIB/PHARMACOLOGY  Guanine Nucleotides/*PHARMACOLOGY  Human  HIV/DRUG
       EFFECTS/*PHYSIOLOGY  Macromolecular Systems
       Oligoribonucleotides/CHEMISTRY/*PHARMACOLOGY  Phosphorylation  Poly
       G/PHARMACOLOGY  Polyribonucleotides/PHARMACOLOGY  Structure-Activity
       Relationship  Thionucleotides/PHARMACOLOGY  T4 Lymphocytes  JOURNAL
       ARTICLE

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